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Sophia O'Brien, MD, MSEd is an Assistant Professor of Clinical Radiology in the Divisions of Nuclear Medicine and Breast Imaging. She completed her Diagnostic Radiology residency, integrated Nuclear Radiology Fellowship, and Breast Imaging Fellowship at Penn. She practices clinical nuclear medicine including interpreting general nuclear medicine studies, PET/CTs, and cardiac nuclear medicine studies, and she treats patients with thyroid disease, neuroendocrine tumor, paraganglioma/pheochromocytoma, and prostate cancer via the Nuclear Therapy Clinic.  She also practices breast imaging including reading mammography, breast US, and breast MRI, and performing imaging-guided breast and axillary biopsies. Dr. O'Brien's research focuses include Fluoroestradiol PET/CT, Radionuclide Therapy, and breast imaging during pregnancy/lactation. She completed her Masters of Medical Education at Penn in 2024 and is passionate about radiology education and education scholarship.


Dr. O'brien's Rating

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3400 Spruce St
Philadelphia, PA, 19104
  • Medicare Accepted
  • Medicaid Accepted
  • Medicare Accepted
  • Medicaid Accepted


  • 3 phase bone scan
  • bone scan spect
  • brain spect
  • cardiac pet scan
  • cisternogram
  • ct scan
  • d spect
  • gastric emptying study
  • hepatobiliary scan
  • hida "
  • i 131 therapy for graves disease"
  • i 131 therapy for thyroid cancer
  • imaging services
  • liver scan
  • lung scan quant perfusion "
  • meckels scan"
  • mpi spect
  • muga
  • myelogram
  • parathyroid scan
  • perfusion imaging of the brain
  • pet bone
  • pet ct of the whole body
  • pet ct scan
  • pet ct skull base to mid thigh
  • pet myocardial imaging metabolic evaluation
  • pet scan brain
  • radioisotope renography
  • rbc scan
  • renal scan flow


  • Diagnostic Radiologist


Lankenau Hospital
Graduated 2017
Medical School
Columbia University
Graduated 2016


Please verify insurance information directly with your doctor's office as it may change frequently.
  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Centivo Health Plan
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • Geisinger Medicaid
  • Global Medical Management
  • HealthAmerica / HealthAssurance a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans/Claim Watcher
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Humana / Medicare
  • Imagine Health 360
  • Independence Blue Cross (Keystone East)
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare


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